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Peter J Smith Selected Research

Chloroquine (Aralen)

2/2020Design and synthesis of novel ferrocene-quinoline conjugates and evaluation of their electrochemical and antiplasmodium properties.
10/2018Chemical Proteomics and Super-resolution Imaging Reveal That Chloroquine Interacts with Plasmodium falciparum Multidrug Resistance-Associated Protein and Lipids.
4/2016Cyclopalladated organosilane-tethered thiosemicarbazones: novel strategies for improving antiplasmodial activity.
11/2015Antimalarial activity of ruthenium(II) and osmium(II) arene complexes with mono- and bidentate chloroquine analogue ligands.
6/2015Optimization of a multi-well colorimetric assay to determine haem species in Plasmodium falciparum in the presence of anti-malarials.
3/2015Synthesis of functionalized 3-, 5-, 6- and 8-aminoquinolines via intermediate (3-pyrrolin-1-yl)- and (2-oxopyrrolidin-1-yl)quinolines and evaluation of their antiplasmodial and antifungal activity.
12/2014Pentacycloundecylamines and conjugates thereof as chemosensitizers and reversed chloroquine agents.
6/2014Synthesis and in vitro biological evaluation of aminoacridines and artemisinin-acridine hybrids.
1/2014Synthesis and evaluation of new polynuclear organometallic Ru(II), Rh(III) and Ir(III) pyridyl ester complexes as in vitro antiparasitic and antitumor agents.
2/2013Structural characteristics of chloroquine-bridged ferrocenophane analogues of ferroquine may obviate malaria drug-resistance mechanisms.
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Peter J Smith Research Topics

Disease

31Malaria
02/2020 - 07/2002
10Tuberculosis (Tuberculoses)
05/2014 - 09/2006
8Neoplasms (Cancer)
12/2017 - 09/2012
6Falciparum Malaria (Plasmodium falciparum Malaria)
11/2015 - 03/2005
4Pulmonary Tuberculosis
01/2015 - 09/2006
3Body Weight (Weight, Body)
06/2012 - 12/2006
2Acquired Immunodeficiency Syndrome (AIDS)
01/2015 - 09/2012
2HIV Infections (HIV Infection)
06/2009 - 06/2008
2Infections
05/2007 - 09/2005
1Autistic Disorder (Autism)
10/2021
1Autism Spectrum Disorder
10/2021
1Uterine Cervical Neoplasms (Cancer of the Cervix)
06/2014
1Nausea
03/2014
1Ovarian Neoplasms (Ovarian Cancer)
01/2014
1Pneumonia (Pneumonitis)
11/2012
1Trypanosomiasis
06/2012
1Leishmaniasis
06/2012
1Ankle Injuries (Ankle Injury)
06/2012
1Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis)
01/2012
1Parasitemia
10/2011
1Cerebral Malaria
07/2011
1Glucose Intolerance
07/2010
1Kwashiorkor
06/2009
1Mycoses (Diseases, Fungus)
05/2007
1Osteoid Osteoma
06/2006
1Melanoma (Melanoma, Malignant)
02/2002
1Leukemia
02/2002
1Wilms Tumor (Wilm's Tumor)
02/2002
1Breast Neoplasms (Breast Cancer)
02/2002
1Desmoplastic Small Round Cell Tumor
02/2002

Drug/Important Bio-Agent (IBA)

17Chloroquine (Aralen)FDA LinkGeneric
02/2020 - 05/2004
11Antimalarials (Antimalarial Agents)IBA
02/2020 - 10/2010
9Rifampin (Rifampicin)FDA LinkGeneric
05/2014 - 12/2007
6Pharmaceutical PreparationsIBA
01/2015 - 06/2004
6Isoniazid (Ftivazide)FDA LinkGeneric
05/2014 - 12/2007
5PyrazinamideFDA LinkGeneric
05/2014 - 09/2006
4hemozoinIBA
10/2018 - 10/2013
3pyrimethamine drug combination fanasil (Fansidar)FDA Link
12/2006 - 03/2005
2LigandsIBA
11/2015 - 03/2012
2QuinolinesIBA
09/2015 - 03/2015
2efavirenz (Sustiva)FDA Link
01/2015 - 04/2009
2Biological ProductsIBA
06/2012 - 05/2005
24-aminoquinolineIBA
06/2012 - 05/2005
2Ethambutol (Myambutol)FDA LinkGeneric
06/2012 - 09/2011
2artenimol (dihydroartemisinin)IBA
05/2011 - 12/2006
2LopinavirFDA Link
01/2011 - 04/2008
2Ritonavir (Norvir)FDA Link
01/2011 - 04/2008
2Pyrimethamine (Daraprim)FDA Link
12/2006 - 09/2005
1Biomarkers (Surrogate Marker)IBA
10/2021
1quinolineIBA
10/2018
1AntioxidantsIBA
03/2016
1Quinacrine (Mepacrine)IBA
03/2016
1Methylene Blue (Methylthioninium Chloride)FDA Link
03/2016
1Melphalan (Alkeran)FDA LinkGeneric
06/2014
1Cisplatin (Platino)FDA LinkGeneric
01/2014
1EmulsionsIBA
10/2013
1LipidsIBA
10/2013
1Hemin (Panhematin)FDA Link
10/2013
1dioleinIBA
10/2013
1EnzymesIBA
08/2013
1ferroquineIBA
02/2013
1diethylenetriamineIBA
09/2012
1Etoposide (VP 16)FDA LinkGeneric
09/2012
1manganese cyclopentadienyl tricarbonylIBA
06/2012
1AlkaloidsIBA
01/2012
1Antitubercular AgentsIBA
01/2012
1Ofloxacin (Ofloxacine)FDA LinkGeneric
01/2012
1artemisinin (artemisinine)IBA
07/2011
1SolventsIBA
05/2011
1ArtemetherFDA Link
05/2011
1Verapamil (Calan)FDA LinkGeneric
05/2011
1GoldIBA
10/2010
1falcipain 2IBA
10/2010
1Cysteine Proteases (Cysteine Protease)IBA
10/2010
1trans-sodium crocetinate (crocetin)IBA
10/2010
1Stavudine (Zerit)FDA LinkGeneric
07/2010
1Glucose (Dextrose)FDA LinkGeneric
07/2010
1fucoxanthinIBA
11/2008
12-methyl-1,4-benzoquinoneIBA
11/2008
1Nevirapine (Viramune)FDA Link
02/2008
1Gatifloxacin (Zymar)FDA Link
12/2007
1liposomal amphotericin BFDA Link
05/2007
1AcidsIBA
04/2007
1Sulfadoxine (Sulformethoxine)FDA Link
12/2006
1ArtesunateIBA
12/2006
1IsatinIBA
05/2005
1Adenosine Triphosphatases (ATPase)IBA
05/2005
1Folic Acid (Vitamin M)FDA LinkGeneric
03/2005
1IronIBA
07/2002
1Heme (Haem)IBA
07/2002
1Proteins (Proteins, Gene)FDA Link
02/2002
1Protein Isoforms (Isoforms)IBA
02/2002

Therapy/Procedure

6Drug Therapy (Chemotherapy)
12/2017 - 07/2011
4Therapeutics
01/2015 - 02/2008
2Complementary Therapies (Alternative Medicine)
12/2017 - 09/2016
1Medical Day Care (Partial Hospitalization)
09/2016
1Braces
06/2012
1Oral Administration
10/2011
1Emergency Treatment
12/2006
1Radiofrequency Ablation
06/2006